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Strategies for hepatitis C therapeutic intervention: now and next

Seng-Lai Tan, Yupeng He, Ying Huang, Michael Gale Jr

Journal:

Current Opinion in Pharmacology

Year:

2004

Language:

english

File:

PDF, 126 KB

english, 2004

Protein kinase C isozymes as potential therapeutic targets in immune disorders

Lee, Matthew R, Duan, Wei, Tan, Seng-Lai

Journal:

Expert Opinion on Therapeutic Targets

Year:

2008

Language:

english

File:

PDF, 3.14 MB

english, 2008

Discovery of Small-Molecule Inhibitors of HCV NS3-4A Protease as Potential Therapeutic Agents against HCV Infection

Chen, Shu-Hui, Tan, Seng-Lai

Journal:

Current Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 498 KB

english, 2005

[Methods in Pharmacology and Toxicology] Immuno-Oncology (Cellular and Translational Approaches) ||

Tan, Seng-Lai

Year:

2020

File:

PDF, 9.93 MB

2020

Mechanistic link between the anti-HCV effect of interferon gamma and control of viral replication by a ras-MAPK signaling cascade

Ying Huang, Xinyi Cynthia Chen, Madhavi Konduri, Nadejda Fomina, Jin Lu, Ling Jin, Alexander Kolykhalov, Seng-Lai Tan

Journal:

Hepatology

Year:

2006

Language:

english

File:

PDF, 335 KB

english, 2006

Selective role of PKCβ enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking

Chandrasekar Venkataraman, Xinyi Cynthia Chen, Songqing Na, Linda Lee, Kuldeep Neote, Seng-Lai Tan

Journal:

Immunology Letters

Year:

2006

Language:

english

File:

PDF, 370 KB

english, 2006

Systems biology and the host response to viral infection

Tan, Seng-Lai, Ganji, Gopinath, Paeper, Bryan, Proll, Sean, Katze, Michael G

Journal:

Nature Biotechnology

Year:

2007

Language:

english

File:

PDF, 863 KB

english, 2007

Hepatitis C therapeutics: current status and emerging strategies

Tan, Seng-Lai, Pause, Arnim, Shi, Yuguang, Sonenberg, Nahum

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 740 KB

english, 2002

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

Michael J. Gale Jr., Marcus J. Korth, Norina M. Tang, Seng-Lai Tan, Deborah A. Hopkins, Thomas E. Dever, Stephen J. Polyak, David R. Gretch, Michael G. Katze

Journal:

Virology

Year:

1997

Language:

english

File:

PDF, 1.15 MB

english, 1997

Ser2194 Is a Highly Conserved Major Phosphorylation Site of the Hepatitis C Virus Nonstructural Protein NS5A

Michael G. Katze, Bart Kwieciszewski, David R. Goodlett, Collin M. Blakely, Petra Neddermann, Seng-Lai Tan, Rudolph Aebersold

Journal:

Virology

Year:

2000

Language:

english

File:

PDF, 316 KB

english, 2000

How Hepatitis C Virus Counteracts the Interferon Response: The Jury Is Still out on NS5A

Seng-Lai Tan, Michael G. Katze

Journal:

Virology

Year:

2001

Language:

english

File:

PDF, 247 KB

english, 2001

The very C-terminus of protein kinase Cɛ is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1

Yimin Zhu, Derek Smith, Chandra Verma, Wee Guan Lim, Bee Jen Tan, Jeffrey S. Armstrong, Shufeng Zhou, Eli Chan, Seng-Lai Tan, Yi-Zhun Zhu, Nam Sang Cheung, Wei Duan

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 766 KB

english, 2006

The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling

Wee Guan Lim, Bee Jen Tan, Yimin Zhu, Shufeng Zhou, Jeffrey S. Armstrong, Qiu Tian Li, Qihan Dong, Eli Chan, Derek Smith, Chandra Verma, Seng-Lai Tan, Wei Duan

Journal:

Cellular Signalling

Year:

2006

Language:

english

File:

PDF, 515 KB

english, 2006

Emerging host cell targets for hepatitis C therapy

Yupeng He, Wei Duan, Seng-Lai Tan

Journal:

Drug Discovery Today

Year:

2007

Language:

english

File:

PDF, 404 KB

english, 2007

Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?

Ying Huang, Kirk Staschke, Raffaele De Francesco, Seng-Lai Tan

Journal:

Virology

Year:

2007

Language:

english

File:

PDF, 478 KB

english, 2007

Using Genetic Means to Dissect Homologous and Heterologous Protein–Protein Interactions of PKR, the Interferon-Induced Protein Kinase

Seng-Lai Tan, Michael G Katze

Journal:

Methods

Year:

1998

Language:

english

File:

PDF, 3.12 MB

english, 1998

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Yi-Hung Ou, Michael Torres, Rosalyn Ram, Etienne Formstecher, Christina Roland, Tzuling Cheng, Rolf Brekken, Ryan Wurz, Andrew Tasker, Tony Polverino, Seng-Lai Tan, Michael A. White

Journal:

Molecular Cell

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

B-Cell Antigen Receptor Signaling in Chronic Lymphocytic Leukemia: Therapeutic Targets and Translational Opportunities

Hill, Ronald J., Lou, Yan, Tan, Seng-Lai

Journal:

International Reviews Of Immunology

Year:

2013

Language:

english

File:

PDF, 654 KB

english, 2013

Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders

Tan, Seng-Lai, Liao, Cheng, Lucas, Matthew C., Stevenson, Christopher, DeMartino, Julie A.

Journal:

Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.09 MB

english, 2013

MANCHESTER.

Hsu, Jonathan, Gu, Yajuan, Tan, Seng-Lai, Narula, Satwant, DeMartino, Julie A., Liao, Cheng

Journal:

The Lancet

Year:

1901

Language:

english

File:

PDF, 425 KB

english, 1901

Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints

Hsu, Jonathan, Gu, Yajuan, Tan, Seng-Lai, Narula, Satwant, DeMartino, Julie A., Liao, Cheng

Journal:

Immunology Letters

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

NS5A, a Nonstructural Protein of Hepatitis C Virus, Binds Growth Factor Receptor-Bound Protein 2 Adaptor Protein in a Src Homology 3 Domain/Ligand-Dependent Manner and Perturbs Mitogenic Signaling

Seng-Lai Tan, Haruhisa Nakao, Yupeng He, Sangeetha Vijaysri, Petra Neddermann, Bertram L. Jacobs, Bruce J. Mayer and Michael G. Katze

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.48 MB

english, 1999

Inactivation of the PKR Protein Kinase and Stimulation of mRNA Translation by the Cellular Co-Chaperone P58 IPK Does Not Require J Domain Function †

Yan, Wei, Gale,, Michael J., Tan, Seng-Lai, Katze, Michael G.

Journal:

Biochemistry

Year:

2002

Language:

english

File:

PDF, 292 KB

english, 2002

Synergistic Antiviral Activity of Human Interferon Combinations in the Hepatitis C Virus Replicon System

Larkin, Jonathan, Jin, Ling, Farmen, Mark, Venable, Daryl, Huang, Ying, Tan, Seng-Lai, Glass, John I.

Journal:

Journal of Interferon & Cytokine Research

Year:

2003

Language:

english

File:

PDF, 297 KB

english, 2003

Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?

Lucas, Matthew C, Tan, Seng-Lai

Journal:

Future Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.14 MB

english, 2014

Biochemical and Genetic Evidence for Complex Formation Between the Influenza A Virus NS1 Protein and the Interferon-induced PKR Protein Kinase

TAN, SENG-LAI, KATZE, MICHAEL G.

Journal:

Journal of Interferon & Cytokine Research

Year:

1998

Language:

english

File:

PDF, 4.12 MB

english, 1998

Cytokine-Activated Natural Killer Cells Exert Direct Killing of Hepatoma Cells Harboring Hepatitis C Virus Replicons

Larkin, Jonathan, Bost, Anne, Glass, John I., Tan, Seng-Lai

Journal:

Journal of Interferon & Cytokine Research

Year:

2006

Language:

english

File:

PDF, 559 KB

english, 2006

The Emerging Role of the Interferon-Induced PKR Protein Kinase as an Apoptotic Effector: A New Face of Death?

Tan, Seng-Lai, Katze, Michael G.

Journal:

Journal of Interferon & Cytokine Research

Year:

1999

Language:

english

File:

PDF, 261 KB

english, 1999

Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights

Hashizume, Misato, Tan, Seng-Lai, Takano, Junichi, Ohsawa, Kazunori, Hasada, Ikuo, Hanasaki, Akira, Ito, Ichiro, Mihara, Masahiko, Nishida, Keiichiro

Journal:

International Reviews Of Immunology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

The Last 10 Amino Acid Residues beyond the Hydrophobic Motif Are Critical for the Catalytic Competence and Function of Protein Kinase Cα

Yeong, Sui Sum, Zhu, Yimin, Smith, Derek, Verma, Chandra, Lim, Wee Guan, Tan, Bee Jen, Li, Qiu Tian, Cheung, Nam Sang, Cai, Minnie, Zhu, Yi-Zhun, Zhou, Shu-Feng, Tan, Seng-Lai, Duan, Wei

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.39 MB

english, 2006

When Translation Meets Metabolism: Multiple Links to Diabetes

Shi, Yuguang, Taylor, Simeon I., Tan, Seng-Lai, Sonenberg, Nahum

Journal:

Endocrine Reviews

Year:

2003

Language:

english

File:

PDF, 446 KB

english, 2003

Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer

Maskos, Klaus, Lammens, Alfred, Tan, Seng-Lai, Hess, Henry, Palinsky, Wolf, Schneider, Pascal, Jiang, Xuliang

Journal:

Data in Brief

Year:

2016

Language:

english

File:

PDF, 281 KB

english, 2016

NS5A - From Obscurity to New Target for HCV Therapy

Schmitz, Uli, Tan, Seng-Lai

Journal:

Recent Patents on Anti-Infective Drug Discovery

Year:

2008

Language:

english

File:

PDF, 474 KB

english, 2008

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

Gale, Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.35 MB

english, 1998

Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain

Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., Hinnebusch, Alan G.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.66 MB

english, 1998

Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58 IPK Inhibitor

Tan, Seng-Lai, Gale, Michael J., Katze, Michael G.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 2.28 MB

english, 1998

Emerging and diverse roles of protein kinase C in immune cell signalling

TAN, Seng-Lai, PARKER, Peter J.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003